Protein Function

Early stage -- single phrase

• Some misleading gene names




Systematic representation

• Single organism
  • MIPS functional classification catalog
  • GenProtEC (E. coli)
  • FlyBase (Drosophila)
  • EGAD (human ESTs)


• Enzyme function
  • ENZYME


• Pathways:
  • EcoCyc
  • WIT
  • KEGG


• Common source for multiple organism functional classification
  • Gene Ontology Project


• Protein iteraction networks
  • DIP
  • Pronet Database
  • Biomolecular Interaction Network Database




Integrated studies on protein function

• Steven E. Brenner at Berkeley
• Janet Thornton at UCL
• Barry Honig at Columbia
• Andrey Rzhetsky and Bill Noble (with Paul Pavlidis) at the Columbia Genome Center
• David Eisenberg at UCLA
• Eugene V. Kooninat NCBI